1. GenBank: The Nucleotide Sequence Database
A1\;6W: Ilene Mizrachi
h vGb9 Created: October 9, 2002
dW!T.S Updated: August 22, 2007
hW>@jT"t1C Summary
~v9\4O The GenBank sequence database is an annotated collection of all publicly available nucleotide
oHu0] XA sequences and their protein translations. This database is produced at National Center for
blaxUP: Biotechnology Information (NCBI) as part of an international collaboration with the European Molecular
L< QqQ"` Biology Laboratory (EMBL) Data Library from the European Bioinformatics Institute (EBI) and the DNA
5nqj Data Bank of Japan (DDBJ). GenBank and its collaborators receive sequences produced in
^`=Z=C$fj laboratories throughout the world from more than 100,000 distinct organisms. GenBank continues to
0_qqBL. 4 grow at an exponential rate, doubling every 10 months. Release 134, produced in February 2003,
K*;=^PY
contained over 29.3 billion nucleotide bases in more than 23.0 million sequences. GenBank is built
EEn}Gw by direct submissions from individual laboratories, as well as from bulk submissions from large-scale
w{K_+}fAC sequencing centers.
|/Zp Z7 Direct submissions are made to GenBank using BankIt [
http://www.ncbi.nlm.nih.gov/BankIt/],
8Z/P<u which is a Web-based form, or the stand-alone submission program, Sequin [http://
athU www.ncbi.nlm.nih.gov/Sequin/index.html]. Upon receipt of a sequence submission, the GenBank staff
2}I1z_dq~ assigns an Accession number to the sequence and performs quality assurance checks. The
nd_d tsp# submissions are then released to the public database, where the entries are retrievable by Entrez or
XkuNLs4 downloadable by FTP. Bulk submissions of Expressed Sequence Tag (EST), Sequence Tagged Site
Thw E1M (STS), Genome Survey Sequence (GSS), and High-Throughput Genome Sequence (HTGS) data are
69r<Z most often submitted by large-scale sequencing centers. The GenBank direct submissions group also
292e0cE processes complete microbial genome sequences.
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