主要研究方向: 1)腫瘤發生中腫瘤細胞和免疫系統相互作用的細胞
分子機制；2）細胞轉化和腫瘤發生、進展的分子基礎，關注細胞轉化中衰老逃逸的機制、腫瘤相關蛋白的泛素化-去泛素化失衡的
生物學效應等。研究目標于發現腫瘤發生的新機制、建立可干預腫瘤發生、發展的新靶點、新策略。
{7![3`%7 項目主要涉及去泛素化酶、轉錄因子等在細胞轉化、衰老逃逸、腫瘤免疫耐受、調節性T細胞發育的作用。相關文章發表在Nature communications, Nature Immunology, Hepatology, Eur J Immunol等雜志。
sAjKf\][ F3Ak'h{Ay 招生單位：
上海交通大學醫學院（仁濟醫院/上海市腫瘤研究所）；課題組網址：
http://www.shsci.org/newslist.aspx?id=136 聯系電郵：
liuyzg@shsci.org ofPF} y5AXL5 近期主要文章：
%M;_(jda 1. Boshi Wang, Aihui, Ma, Li Zhang, Wei-Lin Jin, Yu Qian, Guiqin Xu, Bijun Qiu, Zhaojuan Yang, Yun Liu, Qiang Xia, Yongzhong Liu*. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nature Communications.
2015 Oct 29;6:8704.
e2-70UvW^ 2.Guiqin Xu, Li Zhang, Aihui, Ma, Yu Qian, Yun Liu, Boshi Wang, Zhaojuan Yang, Yongzhong Liu*. SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells. Oncotarget. 2015 Oct 20;6(32):33636-47.
eA*Jfb 3. Li Zhang, Zhaojuan Yang, Aihui Ma, Yulan Qu, Suhua Xia, Dongxu Xu, Chao Ge, Bijun Qiu, Qiang Xia, Jinjun Li, Yongzhong Liu*. Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma. Hepatology. 2014; 59(1):178-89.
gSv[4,hXd 4. Li Zhang, Zhaojuan Yang , Yongzhong Liu*. GADD45 proteins: roles in cellular senescence and tumor development. Exp Biol Med (Maywood). 2014 28; 239 (7):773-778
;oY(I7 5. Yun Liu, Yingqian Xu, Jiabin Sun, Aihui Ma, Feng Zhang, Suhua Xia, Guiqin Xu, Yongzhong Liu*. AKT hyperactivation confers a Th1 phenotype in thymic Treg cells deficient in TGF-β receptor II signaling. Eur J Immunol. 2014; 44(2):521-32.
e0|_Z])D 6. Jiabin Sun, Boshi Wang, Yun Liu, Li Zhang, Aihui Ma, Zhaojuan Yang, Yuhua Ji, Yongzhong Liu*. Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression. Cancer Lett. 2014 ; 355(1):25-33.
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