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Hallmarks of Cancer: New Dimensions. Muarryh}  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast h>\}-|Ek  
complexity of cancer phenotypes and genotypes into a provisional set of underly- X.JB&~/rO  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have FCI38?`%  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- S_\RQB\l  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- Cu!4ha.e`  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 亚洲国产精品va在线观看麻豆