腫瘤方面考博必讀文獻

Hallmarks of Cancer: New Dimensions. uwGc@xOgg,  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast j0q&&9/Jj  
complexity of cancer phenotypes and genotypes into a provisional set of underly- Xsa].  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have qJ-/7-$ ^  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- b& U62iq  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- y?3;06y|  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 'LDQgC*%  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added wUJcmM;  
to the roster of functionally important cell types in the tumor microenvironment.