Hallmarks of Cancer: New Dimensions. 6{2 9cX.
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast um$L;-2:
complexity of cancer phenotypes and genotypes into a provisional set of underly- Kk/cI6`W
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have 3$ BYfI3H
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- ;})s o
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- n<MreKixE
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate 8z* /J=n
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added '];=1loD
to the roster of functionally important cell types in the tumor microenvironment.
